The Prokinetic Effect of Mosapride Citrate on Horse Gastric Emptying Rates

Journal of Veterinary Medical Science

Morito FUKUNAKA²  Naoki SASAKI²  Haruo YAMADA²  Hisashi INOKUMA²  Koichi OKAMURA¹ 

[1] The United Graduate School of Veterinary Sciences, Gifu University;Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine

关键词: equine;    gastric emptying rate;    mosapride citrate;   

DOI  :  10.1292/jvms.70.627

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(15)Cited-By(4)The prokinetic effect of the 5-HT4 receptor agonist mosapride was evaluated in seven healthy thoroughbreds. Mosapride was orally administerd at doses of 0.5, 1.0 or 1.5 mg/kg. The breath 13CO2/12CO2 rate (Δ13CO2), an indirect indicator for the rate of gastric empting, was measured at appropriate points for 4 hr after drug administration. There was a significant increase compared with the control value at 15, 20 and 165 min for 0.5 mg/kg, 30 min at 1.0 mg/kg and 165 min for 1.5 mg/kg. The results suggest that mosapride may facilitate the gastric emptying in horses.

【 授权许可】

Unknown