Journal of Veterinary Medical Science | |
Pharmacokinetics of the Gastroprokinetic Agent Mosapride Citrate after Single Oral Administration in Horses | |
Morito FUKUNAKA2  Naoki SASAKI2  Haruo YAMADA2  Hisashi INOKUMA2  Koichi OKAMURA1  | |
[1] The United Graduate School of Veterinary Sciences, Gifu University;Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine | |
关键词: equine; gastric emptying rate; mosapride citrate; | |
DOI : 10.1292/jvms.09-0321 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(12)Cited-By(3)The purpose of this study was to determine the pharmacokinetics and dose proportionality of mosapride citrate, a selective 5-HT4 agonist, after oral administration in horses. Seven healthy Thoroughbreds were dosed with distilled water and 0.5, 1.0, or 1.5 mg/kg mosapride citrate through a nasogastric tube. Serum mosapride concentrations were measured by a liquid chromatography/tandem mass spectrometry (LC/MS/MS) method. Mosapride showed the Cmaxs of 31, 60, and 104 ng/g and AUCs of 178, 357, and 566 ng·hr/g at doses of 0.5, 1.0, 1.5 mg/kg, respectively. The Cmaxs and AUCs increased in proportion to the dose, indicating linear pharmacokinetics of mosapride up to 1.5 mg/kg. The pharmacokinetic profiles of mosapride in horses are quite different from that in humans. The average t1/2 in horses was almost 2 fold longer than that reported in healthy adult humans. Therefore, it is thought that it is suitable to reduce the number of doses a day in horses compared to humans.
【 授权许可】
Unknown
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RO201911300224804ZK.pdf | 622KB | download |