Mexiletine Reverses Oxaliplatin-Induced Neuropathic Pain in Rats

Journal of Pharmacological Sciences

Shingo Hirakawa¹  Hiroaki Ikesue¹  Nobuaki Egashira¹  Takahisa Yano¹  Ryozo Oishi¹  Takehiro Kawashiri¹ 

[1] Department of Pharmacy, Kyushu University Hospital, Japan

关键词: mexiletine;    oxaliplatin;    neuropathic pain;   

DOI  :  10.1254/jphs.10012SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(14)Cited-By(19)Oxaliplatin is a platinum-based chemotherapy drug characterized by the development of acute and chronic peripheral neuropathies. Mexiletine, an orally available Na+-channel blocker, has widely been used in patients with chronic painful diabetic neuropathy. In the present study, we examined the effect of mexiletine on oxaliplatin-induced neuropathic pain in rats. Mexiletine (100, but not 10 and 30, mg/kg, p.o.) completely reversed both mechanical allodynia and cold hyperalgesia induced by oxaliplatin (4 mg/kg, i.p., twice a week). Lidocaine (30, but not 3 and 10, mg/kg, i.p.) also significantly relieved both pain behaviors. These results suggest that mexiletine may be effective in relieving the oxaliplatin-induced neuropathic pain clinically.

【 授权许可】

Unknown