Effect of Mexiletine on Dynamic Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats

Journal of Veterinary Medical Science

Sachi TANIMOTO-MORI²  Yoichi KUREBAYASHI¹  Etsuko NAKAZATO-IMASATO² 

[1] Kobe University Office of Collaborative Research and Technology Development, Kobe University;Nagoya Discovery Research, Pfizer Global Research and Development, Pfizer Inc.

关键词: dynamic allodynia;    mexiletine;    neuropathic pain;    pregabalin;    static allodynia;   

DOI  :  10.1292/jvms.71.991

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(5)Static and dynamic allodynia occurred in a rat model of neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve. Static allodynia was detected within 1 day after the CCI surgery, and persisted for 28 days. Dynamic allodynia displayed a slower course of development with a late onset, and statistically significant changes were achieved between 14 and 28 days after the surgery. Mexiletine at 10 and 30 mg/kg, s.c. produced a significant and dose-dependent inhibition of CCI-induced static and dynamic allodynia on day 14 post-surgery. Pregabalin, used as a reference drug, also significantly inhibited both static and dynamic allodynia at 30 and 60 mg/kg, p.o. These findings rationalize the clinical use of mexiletine for treatment of neuropathic pain.

【 授权许可】

Unknown