BirdsAnts: タンパク質－低分子化合物相互作用ビューア

Chem-Bio Informatics Journal

荒木 健司¹  �?�? 健¹  島田 裕康¹  根本 昌¹  飛田 基¹  西川 哲夫¹ 

[1] リバースプロテオミクス研究所情報科学部門

关键词: visualization;    可視化;    viewer;    ビューア;    matrix;    マトリクス;    interaction;    相互作用;    protein;    タンパク質;    small molecules;    低分子化合物;    drug discovery;    医薬品開発;    clustering;    クラスタリング;    vitamin B12;    ビタミンB12;    COX;   

DOI  :  10.1273/cbij.6.17

学科分类：生物化学/生物物理

来源: Chem-Bio Informatics Society

【 摘 要 】

References(17)A data-matrix viewer, BirdsAnts, is developed for the effective visualization of large scale protein-small molecule interaction data. One of two design concepts is the simultaneous visualization of three kinds of data: data pertaining to proteins, those to small-molecules, and those to interactions between them. The other is switching of global and local views of data back and forth. To evaluate BirdsAnts, a data-matrix was generated by processing a protein-small molecule interaction database. Analyzing the matrix, two known facts were rediscovered. First rediscovery was the knowledge that each function of vitamin B12 is exercised by interaction to a different protein. Second was that cyclooxygenase inhibitors were correctly classified into known classes by two-step clustering calculations. The results of the evaluation show that BirdsAnts has future potential for the effective visualization of protein-small molecule interaction data.

【 授权许可】

Unknown