Cross-Sensitivity of X-Ray-Hypersensitive Cells Derived from LEC Strain Rats to DNA-Damaging Agents

Journal of Veterinary Medical Science

Daiji ENDOH¹  Soichiro ARAI¹  Toyo OKUI¹  Emiko ISOGAI¹  Masanobu HAYASHI¹ 

关键词: alkylating agent;    bleomycin;    cross-sensitivity;    LEC rat cell;    mitomycin C;   

DOI  :  10.1292/jvms.58.11_1067

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(33)Cited-By(9)The cross-sensitivity of X-ray-hypersensitive lung fibroblasts from LEC strain (LEC) rats to othet DNA-damaging agents was examined. The LEC cells were 2- to 3-fold more sensitive to bleomycin (BLM) that induces DNA double-strand breaks, and to a cross-linking agent, mitomycin C, than the cells from WKAH strain (WKAH) rats, while they were slightly sensitive to alkylating agents, ethyl nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine, but not to UV-irradiation. Although no difference was observed in the initial yields of DNA double-strand breaks induced by BLM between LEC and WKAH cells, the repair process of DNA double-strand breaks was significantly slower in LEC cells than in WKAH cells.

【 授权许可】

Unknown