Wortmannin, a Radiation Sensitizer, Enhances the Radiosensitivity of WKAH Rat Cells but not That of LEC Rat Cells

Journal of Veterinary Medical Science

Ai KAWANA²  Daiji ENDOH²  Toyo OKUI¹  Masanobu HAYASHI² 

[1] Hokkaido Institute of Public Health, Sapporo 060-0819, Japan;Department of Veterinary Radiology, Faculty of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-8501, Japan

关键词: DNA-dependent protein kinase;    LEC rat cell;    wortmannin;   

DOI  :  10.1292/jvms.62.191

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(36)Cited-By(2)No significant cytotoxic effect was observed in WKAH rat cells by the treatment of wortmannin, a radiation sensitizer, at concentrations lower than 30 μM for 24 hr. The relative surviving fractions of LEC rat cells were slightly, but significantly, lower than those of WKAH rat cells at each concentration of wortmannin. When the wortmannin-treated WKAH rat cells were X-irradiated, the relative surviving fractions decreased in a wortmannin concentration-dependent manner. On the contrary, no significant difference was observed between the survival curves of untreated and wortmannin-treated LEC rat cells after X-irradiation.

【 授权许可】

Unknown