Impairment of Early Insulin Response after Glucose Load, Rather than Insulin Resistance, is Responsible for Postprandial Hyperglycemia Seen in Obese Type 2 Diabetes

Endocrine Journal

KYOKO NISHIYAMA¹  MASATAKA NIWA¹  TOMOAKI SHIMIZU¹  HIROSHI UCHINO¹  RYUZO KAWAMORI¹ 

[1] Department of Medicine, Metabolism & Endocrinology, Juntendo University School of Medicine

关键词: Type 2 diabetes;    Early prandial insulin secretion;    Nateglinide;    Insulin resistance;    Obesity;   

DOI  :  10.1507/endocrj.47.639

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(5)Cited-By(35)The insulin secretory pattern as a phenotype of type 2 diabetes is an impairment in the rapid, pulsatile secretion of insulin in response to a rise in blood glucose after meal-intake. The restoration of endogenous rapid insulin secretion after oral glucose load was established for the first time by using nateglinide, which is a newly developed insulin secretagogue, in obese patients with type 2 diabetes mellitus. It was clearly demonstrated that with the nateglinide, serum insulin levels were quickly raised, and glycemic response curves were almost normalized with the same amount of insulin secretion during 180min. Therefore, the lack of rapid, pulsatile secretion of insulin in response to glycemic rise after oral glucose load, rather than insulin resistance, is responsible for postprandial glycemic response in obese type 2 diabetes patients.

【 授权许可】

Unknown