Modulation of 8-OH-DPAT-Induced Hypothermia by Imipramine in Rats

Journal of Pharmacological Sciences

Kazuhiko Shibata²  Yoshiro Tanizaki³  Hiroaki Araki⁴  Yoshihisa Kitamura¹  Yutaka Gomita² 

[1] Division of Pharmacy, Misasa Medical Center, Okayama University Medical School;Department of Hospital Pharmacy, Okayama University Medical School;Division of Medicine, Misasa Medical Center, Okayama University Medical School;Division of Hospital Pharmacy, Ehime University Hospital

关键词: imipramine;    8-OH-DPAT;    hypothermia;    5-HT1A receptor;    5-HT2A receptor;   

DOI  :  10.1254/jphs.93.259

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(20)Cited-By(1)The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)1A-receptor full agonist, -induced hypothermia was examined in rats. Single administration of imipramine (30 mg/kg, i.p.) attenuated 8-OH-DPAT-induced hypothermia. This effect of imipramine was blocked by the 5-HT2A-receptor antagonist ketanserin. 8-OH-DPAT-induced hypothermia was not altered 24 h after repeated administration of imipramine (1 – 10 mg/kg per day) for 14 days. However, 8-OH-DPAT-induced hypothermia was significantly enhanced in repeated imipramine (10 mg/kg per day)-treated rats that received 8-OH-DPAT plus imipramine 24 h after the final imipramine administration for 14 days. The 5-HT2A-receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane ((±)-DOI) attenuated the 8-OH-DPAT-induced hypothermia in drug naive rats. The inhibitory effect of (±)-DOI (0.3 mg/kg, s.c.) on 8-OH-DPAT-induced hypothermia was attenuated by repeated administration of imipramine (10 mg/kg per day) for 14 days. These findings suggest that enhancement of the 5-HT1A receptors by repeated administration of imipramine may be due to reduction of the inhibitory effects from the 5-HT2A receptors to the 5-HT1A receptors.

【 授权许可】

Unknown