Expressions of Protein Oxidation Markers, Dityrosine and Advanced Oxidation Protein Products in Cisplatin-Induced Nephrotoxicity in Rats

Journal of Veterinary Medical Science

Atsushi ASANO³  Takashi TAKEUCHI⁴  Aino MASUDA¹  Tairin OCHI¹  Masaaki NISHINOHARA⁴  Yumi KIMOTO²  Akihiko SUGIYAMA⁴ 

[1] Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.;United Graduate School of Veterinary Science, Yamaguchi University;Course of Veterinary Biochemistry, School of Veterinary Medicine, Faculty of Agriculture, Tottori University;Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

关键词: advanced oxidation protein product;    cisplatin;    dityrosine;    nephrotoxicity;    oxidative stress;   

DOI  :  10.1292/jvms.10-0371

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Cited-By(3)The purpose of this study was to evaluate whether dityrosine and advanced oxidation protein products (AOPP) reflect the severity of cisplatin-induced nephrotoxicity. Immunoexpression of dityrosine in kidneys and plasma AOPP concentration were examined up to day 4 post-cisplatin injection in rats. Cisplatin injection induced tubular injury on days 2-4 after injection and increased serum creatinine and BUN on days 3 and 4. On days 2-4, dityrosine was immunostained in the cytoplasm of damaged tubular cells, and their immunostaining intensity increased time-dependently. Plasma AOPP levels were significantly increased on days 3 and 4. These results suggest that expressions of dityrosine and AOPP were associated with the severity of renal injury and may be useful markers for the development of cisplatin-induced nephrotoxicity.

【 授权许可】

Unknown