Effect of Protein Malnutrition on the Skin Epidermis of Hairless Mice

Journal of Veterinary Medical Science

Yuka FUJITA³  Takashi TAKEUCHI³  Aino MASUDA¹  Mizuyuki RYU²  Toshihiro KOBAYASHI²  Yasushi SUZUKI²  Tairin OCHI¹  Akihiko SUGIYAMA³ 

[1] Japan Institute for the Control of Aging (JalCA), Nikken Seil Co., Ltd.;Biochemical Laboratory, Saraya Co., Ltd.;Course of Veterinary Laboratory Medicine, School of Veterinary Medicine, Faculty of Agriculture, Tottori University

关键词: advanced oxidation protein product;    dityrosine;    protein malnutrition;    skin epidermis;   

DOI  :  10.1292/jvms.10-0399

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(36)Cited-By(1)The purpose of this study was to evaluate the effect of protein malnutrition on the skin epidermis of mice. A low protein diet induced thinning of the skin epidermis, a decrease of cell proliferative activity in epidermal cells and a decrease of stratum corneum hydration. Dityrosine was immunostained in the cytoplasm of epidermal cells in the low protein diet group. Plasma advanced oxidation protein product (AOPP) levels were significantly more increased in the low protein diet group than in the control diet group. These results suggest that protein malnutrition adversely affects the structure and water barrier and reservoir functions of the skin epidermis, and these pathological changes are associated with the expressions of protein oxidation markers, dityrosine and AOPP.

【 授权许可】

Unknown