Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats

Endocrine Journal

Riyo Kinouchi¹  Satoshi Yamamoto¹  Toshiyuki Yasui¹  Takeshi Iwasa¹  Masahiro Murakami¹  Minoru Irahara¹  Toshiya Matsuzaki¹  Ganbat Gereltsetseg¹  Akira Kuwahara¹  Shinobu Yoshida¹ 

[1] Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan

关键词: Kisspeptin;    Fasting;    Neurokinin B;    Neurokinin 3 receptor;    ARC kisspeptin neuron;   

DOI  :  10.1507/endocrj.K11E-131

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(55)Cited-By(11)Kisspeptin, which is the product of the kiss1 gene and its receptor kiss1r, have emerged as the essential gatekeepers of reproduction. The present study used gonadally intact female rats to evaluate fasting-induced suppression of the KiSS-1 system of anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) under normal physiological conditions.Starting on the day of estrous, one group of rats was subjected to 72 h of food deprivation, while the other group of rats was able to continue feeding ad libitum.The length of the estrous cycle was significantly longer in the food-deprived rats as compared to the feeding rats.At the end of the 72-h food deprivation period, all of the food-deprived rats were at the diestrous phase, with their serum concentrations of LH and leptin significantly lower than that observed in the feeding rats.In addition, as compared to the feeding rats, the expression levels of kiss1 mRNA were significantly lower in the food-deprived rats in the posterior hypothalamic block, which contained the ARC, but not in the anterior hypothalamic block, which contain the AVPV.However, both the kiss1r mRNA expression levels in the anterior and posterior hypothalamic blocks and the neurokinin B and neurokinin 3 receptor mRNA expression levels in the posterior hypothalamic block were not significantly different between the feeding and food-deprived rats.Thus, lower kiss1 mRNA levels in the ARC appear to be responsible for the fasting-induced inhibition of gonadotrophin secretion and subsequent prolongation of the estrous cycle.

【 授权许可】

Unknown