Obstructive Uropathy and Hydronephrosis in Male KK-Ay Mice: A Report of Cases

Journal of Veterinary Medical Science

Tomo INOMATA²  Kikumi OGIHARA¹  Hiroyoshi NINOMIYA² 

[1] Department of Environmental Pathology, Azabu University 1-17-71 Fuchinobe, Sagamihara 229-8501, Japan;Department of Laboratory Animal Science, Azabu University 1-17-71 Fuchinobe, Sagamihara 229-8501, Japan

关键词: KK-Ay mouse;    obstructive uropathy;    urethral plug;   

DOI  :  10.1292/jvms.61.53

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Cited-By(7)Uropathy associated with hydronephrosis was observed frequently in our male KK-Ay mouse colony during a long-term study of diabetes. The lesion occurred in 24 of the 31 KK-Ay male mice and accounted for the greatest number of spontaneous deaths among them. It was observed after 4 months of age and involved about hard plugs of altered seminal material resembling the seminal vesicle secretion. The plugs became impacted in the urethral bulb and the bladder. The penile anatomy, with its flexure, pressure on the urethra from the bulbocavernosus muscle, and the characteristic ability of the seminal fluid to easily coagulate to form the vaginal plug may have contributed to the lesion. Correlation between development of the uropathy and diabetes has not been established.

【 授权许可】

Unknown