Preliminary Study of Effects of Multiple Oral Dosing of Clarithromycin on thePharmacokinetics of Cyclosporine in Dogs

Journal of Veterinary Medical Science

Rieko KATAYAMA²  Yasuhiko OKAMURA²  Yoshiki KAWAKAMI²  Shunsuke SHIMAMURA¹  Yuji UZUKA²  Masaaki KATAYAMA² 

[1] Division of Small Animal Internal Medicine, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3�?18�?8 Ueda, Morioka, Iwate 020�?8550, Japan;Division of Small Animal Surgery, Co-Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3�?18�?8 Ueda, Morioka, Iwate 020�?8550, Japan

关键词: clarithromycin;    cyclosporine;    pharmacokinetics;    renal transplantation;   

DOI  :  10.1292/jvms.13-0209

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(22)Clarithromycin (CLM) has been known to increase the cyclosporine (CsA) troughlevel in human and feline organ transplant patients. However, the interaction of CLM withCsA has not been reported in dogs. In this study, the effects of multiple dosing of CLM onthe pharmacokinetics of CsA in three healthy beagles were investigated. The treatmentsincluded CsA 10 mg/kg alone and CsA 10 mg/kg + multiple-dose of CLM 10 mg/kg.Co-administration of CLM with CsA resulted in significant increases of oralbioavailability of CsA. The results of our study suggest that administration of multipletherapeutic doses of CLM may decrease the required CsA dosage in CsA-basedimmunosuppressive therapy in renal transplanted dogs.

【 授权许可】

Unknown