Hemodynamic Alterations in Dogs with Shock Induced by Intravenous Injection of Heartworm Extract

Journal of Veterinary Medical Science

Chikao MIKAMI¹  Hitoshi KITAGAWA¹  Katsuya KITOH¹  Yoshihide SASAKI¹ 

[1] Laboratory of Internal Medicine, Division of Veterinary Medicine

关键词: heartworm;    hemodynamics;    shock;   

DOI  :  10.1292/jvms.63.179

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(21)Cited-By(1)To elucidate one way of the shock mechanisms, the hemodynamic alterations were examined in 7 dogs with heartworm (HW) extract-induced shock. The first alteration observed after injection of HW extract was a decrease in right ventricular end-diastolic pressure (RVEDP). After that, left ventricular (LV) end-diastolic pressure, LV systolic pressure, and LV dp/dt fell significantly, followed by a decrease in the cardiac output of all dogs to below the detectable level (1.00 l/min). Since RVEDP depends on blood flow into the right ventricle, the decrease in RVEDP means a reduction in venous return. Therefore, this study showed that the first trigger of a decrease in blood pressure in HW extract-induced shock is the reduction in venous return.

【 授权许可】

Unknown