Hepatocellular Carcinoma in a Hokkaido Brown Bear (Ursus arctos yesoensis)

Journal of Veterinary Medical Science

Hiroyuki TANIYAMA²  Kazuya MATSUDA²  Yoshio KAWAMURA²  Kazuyoshi SASAKI¹  Hiromi SUZUKI²  Yongjin QIU²  Hideyuki SAKAMOTO¹  Yuko TAKITA¹ 

[1] Noboribetsu Bear Park;Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University

关键词: brown bear;    hepatocellular carcinoma;    immunohistochemistry;   

DOI  :  10.1292/jvms.10-0034

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(4)Hepatocellular carcinoma with metastases to lymph nodes and adrenal glands was found in a 26-year-old male Hokkaido brown bear (Ursus arctos yesoensis). Left hepatic lobe was largely replaced by well-differentiated neoplastic cells, whereas poorly differentiated tumor cells had proliferated in part of the left hepatic lobe, in scattered nodules in the remainig liver tissue, and at the metastatic sites. Immunoreactivity for hepatocyte antigen (hepatocyte paraffin 1 antibody) and alpha-fetoprotein was observed in both well- and poorly differentiated neoplastic cells in the liver and metastatic foci. To our knowledge, this case is the first report of hepatocellular carcinoma in brown bears.

【 授权许可】

Unknown