Transient Increases of Glutamic Acid Decarboxylase 67 Immunoreactivity and Its Protein Levels in the Somatosensory Cortex after Transient Cerebral Ischemia in Gerbils

Journal of Veterinary Medical Science

Hua LI¹  In Koo HWANG³  Moo-Ho WON¹  Dae Young KWON²  Ok Kyu PARK¹  Ki-Yeon YOO¹  Choong Hyun LEE³  Jung Hoon CHOI¹ 

[1] Department of Anatomy and Neurobiology, College of Medicine, Hallym University;Korea Food Research Institute;Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University

关键词: GABA;    GAD67;    gerbil;    somatosensory cortex;    transient forebrain ischemia;   

DOI  :  10.1292/jvms.70.1005

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(38)In this study, we investigated changes in glutamic acid decarboxylase 67 (GAD67) immunoreactivity and its protein levels in the gerbil somatosensory cortex after ischemia/reperfusion. GAD67 immunoreactivity was significantly increased in layers III and V of the somatosensory cortex 12 hr after ischemia/reperfusion. Thereafter, GAD67 immunoreactivity was decreased with time after ischemia/reperfusion. GAD67 immunoreactivity in the somatosensory cortex 4 days after ischemia/reperfusion was similar to that in the sham-operated group. In addition, GAD67 protein levels were also significantly increased 12 hr after transient forebrain ischemia. These results suggest that the transient increase of GAD67 immunoreactivity in layers III and V may be associated with responses to transient ischemia-induced neuronal damage.

【 授权许可】

Unknown