Effect of Prenatal Valproic Acid Exposure on Cortical Morphology in Female Mice

Journal of Pharmacological Sciences

Shunsuke Kataoka¹  Kazuhiro Takuma¹  Yuko Maeda¹  Yukio Ago¹  Yuta Hara¹  Toshio Matsuda¹ 

[1] Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan

关键词: autism spectrum disorder;    valproate;    sex difference;   

DOI  :  10.1254/jphs.12025SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(11)We have recently shown that prenatal valproic acid (VPA) exposure causes autism spectrum disorders–like behavioral abnormalities and Nissl-positive cell loss in both prefrontal and somatosensory cortices in male mice. We have also found that VPA-induced social interaction deficits are observed in male but not female offspring. This study demonstrated that the exposure to VPA at embryonic day 12.5 significantly decreased Nissl-positive cell numbers in the prefrontal cortex, but not in the somatosensory cortex, in female offspring. These findings suggest that VPA-induced morphological abnormalities in the somatosensory cortex may be involved in the sex-dependent social interaction deficits.

【 授权许可】

Unknown