Effects of 1,25-dihydroxyvitamin D3 on Macrophage Cytokine Secretion Stimulated by Porphyromonas gingivalis

Japanese Journal of Infectious Diseases

Qing-an Xu¹  Ping Zhang²  Zhao-fei Li¹  Li-hua Cao¹  Ming-wen Fan¹ 

[1] The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University;Department of Pediatric Dentistry, University of Alabama at Birmingham

关键词: 1;    25-dihydroxyvitamin D3;    Porphyromonas gingivalis;    macrophage;    cytokine;    mitogen-activated protein kinase;   

DOI  :  10.7883/yoken.JJID.2015.396

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(35)Vitamin D is known to be closely associated with periodontitis; however, its exact mechanisms remain to be clarified. The present study aimed to investigate the influence of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on Porphyromonas gingivalis (Pg)-stimulated cytokine production and the involved signaling pathways in macrophages. The main observation was that 1,25(OH)2D3 inhibited Pg-induced interleukin (IL)-6 cytokine expression but up-regulated the expression of anti-inflammatory cytokine IL-10. Further analyses showed that 1,25(OH)2D3 decreased p38 mitogen-activated protein kinase (MAPK) and extracellular signal regulated kinase (ERK)1/2 phosphorylation. Inhibited phosphorylation of p38 MAPK and ERK1/2 was associated with decreased level of IL-6 expression, but was not related to increased level of IL-10 expression in macrophages stimulated with Pg. These results suggest that 1,25(OH)2D3 might exert its anti-inflammatory effects on Pg-stimulated macrophages partly through its inhibitory effect on the p38 MAPK and ERK1/2 signaling pathway.

【 授权许可】

Unknown