Inflammatory response to Porphyromonas gingivalis partially requires interferon regulatory factor (IRF) 3:

Innate Immunity

Yazdani BShaik-Dasthagirisaheb¹ 

关键词: Porphyromonas gingivalis;    IRF3;    cytokine;    chemokine;    macrophage;   

DOI  :  10.1177/1753425913492180

学科分类：生物科学（综合）

来源: Sage Journals

【 摘 要 】

Innate immune activation with expression of pro-inflammatory molecules such as TNF-α is a hallmark of the chronic inflammation associated with periodontal disease (PD). Porphyromonas gingivalis, a bacterium associated with PD, engages TLRs and activates MyD88-dependent and TIR-domain-containing adapter-inducing IFN-β (TRIF)-dependent signaling pathways. IFN regulatory factor (IRF) 3 is activated in a TRIF-dependent manner and participates in production of cytokines such as TNF-α; however, little is known regarding IRF3 and the host response to PD pathogens. We speculated that IRF3 participates in the host inflammatory response to P. gingivalis. Our results show that bone marrow macrophages (MØ) from WT mice respond to P. gingivalis with activation and nuclear translocation of IRF3. Compared with WT, MØ from IRF3−/−, TRIF−/−, and TLR4−/− mice responded with reduced levels of TNF-α on P. gingivalis challenge. In addition, full expression of IL-6 and RANTES by MØ to P. gingivalis was dependent on IRF3. Lastl...

【 授权许可】

CC BY