Goshuyuto, a Traditional Japanese Medicine for Migraine, Inhibits Platelet Aggregation in Guinea-Pig Whole Blood

Journal of Pharmacological Sciences

Mitsutoshi Yuzurihara²  Atsushi Takeda¹  Yoshio Kase²  Kiyoshi Terawaki²  Tomoko Hibino²  Hitomi Kanno² 

[1] Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan;Tsumura Research Laboratories, Tsumura & Co., Japan

关键词: goshuyuto;    Evodiae Fructus;    Zingiberis Rhizoma;    6-shogaol;    6-gingerol;   

DOI  :  10.1254/jphs.08058FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(18)Cited-By(14)The effects of goshuyuto and chotosan, traditional Japanese medicines, on collagen-induced platelet aggregation were examined using guinea-pig blood. Goshuyuto at the concentration of 1,000 μg/mL inhibited collagen-induced platelet hyper-aggregation to the same degree as aspirin at the concentration of 100 μmol/L, but chotosan did not. Goshuyuto is composed of four medicinal herbs. Of them, aqueous extracts of Evodiae Fructus and Zingiberis Rhizoma inhibited platelet aggregation, but aqueous extracts of Zizyphi Fructus and Ginseng Radix did not. Two components of Zingiberis Rhizoma, 6-shogaol and 6-gingerol, also inhibited platelet aggregation. These results suggest that Evodiae Fructus and Zingiberis Rhizoma may play important roles in the anti-aggregation effects of goshuyuto and that 6-shogaol and 6-gingerol are among the active ingredients. Therefore, goshuyuto may ameliorate migraine by preventing the hyper-aggregation of platelets in migraine with aura.

【 授权许可】

Unknown