Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors

Journal of Pharmacological Sciences

Mitsutoshi Yuzurihara²  Atsushi Takeda¹  Yoshio Kase²  Tomoko Hibino² 

[1] Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan;Tsumura Research Laboratories, Tsumura & Co., Japan

关键词: Evodiae Fructus;    synephrine;    adrenergic α1;    5-hydroxytryptamine (5-HT)1D;    5-HT2A;   

DOI  :  10.1254/jphs.09077FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(21)Cited-By(6)We investigated the effects of Evodiae Fructus and synephrine, one of the components of Evodiae Fructus, on blood vessels. We found that Evodiae Fructus (1 × 10−6 – 3 × 10−4 g/mL) had constrictive effects on rat aorta. The vasoconstrictive effects of Evodiae Fructus were significantly inhibited by pretreatment with prazosin (adrenergic α1-receptor antagonist), BRL15572 [5-hydroxytryptamine (5-HT)1D antagonist], and ketanserin (5-HT2A antagonist), but its vasoconstrictive effects were not inhibited by pretreatment with SB216641 (5-HT1B antagonist) or propranolol (adrenergic β-receptor antagonist). These results suggest that Evodiae Fructus constricts rat aorta via adrenergic and serotonergic receptors. We also investigated the constrictive effects of synephrine on blood vessels. The vasoconstrictive effects of synephrine (1 × 10−7 – 3 × 10−5 mol/L) were significantly inhibited by pretreatment with prazosin, BRL15572, and ketanserin. However, its constrictive effects were not inhibited by pretreatment with SB216641 and propranolol. The pA2 values of prazosin or ketanserin were nearly equal between Evodiae Fructus and synephrine. Because the constrictive effects of both Evodiae Fructus and synephrine were exerted via adrenergic α1-receptors and serotonergic (5-HT1D and 5-HT2A) receptors, synephrine may be one of the important components in the constrictive effects of Evodiae Fructus.

【 授权许可】

Unknown