Oxidative-nitrosative stress and dengue disease: a systematic review of in vivo/in vitro studies

Revista Cubana de Medicina Tropical

Pinzón-Redondo, Hernando Samuel¹  Castro Orozco, Raimundo²  Alvis-Guzmán, Nelson Rafael³ 

[1] University of San Buenaventura, Cartagena de Indias, Colombia;Children's Hospital Foundation Napoleon Franco Pareja, Cartagena de Indias, Colombia;University of Cartagena, Cartagena de Indias, Colombia

关键词: dengue;    severe dengue;    dengue virus;    oxidative stress;    nitrosative stress;    biological markers;    systematic review (source: MeSH).;   

DOI  :  

学科分类：传染病学

来源: SciELO

【 摘 要 】

Objective: in this systematic reviewthe aim was to summarise the in vivo/in vitro evidence on therole of oxidative-nitrosative stress in pathogenesis of dengue.
Methods: we searched electronicdatabases (PubMed, EMBASE, The COCHRANE library, ScienceDirect, Scopus, SciELO,LILACS via Virtual Health Library, Google Scholar) using the term: dengue, denguevirus, severe dengue, oxidative stress, nitrosative stress, antioxidants, oxidants,free radicals, oxidized lipid products, lipid peroxides, nitric oxide, and nitricoxide synthase. Articles were selected for review by title and abstract excludingletter, review, epidemiological studies, and duplicates studies. Selected articleswere reviewed for used animal model or cell cultures, original purposes, strainof virus or type of antibody, main outcomes, methods, and oxidative-nitrosativestress markers values.
Results: in total, 4330 non-duplicatesarticles were identified from computerized searches of reference databases,of which 32 were eligible for full text searching. The results of in vivostudies were obtained from monkey and knockout and/or wild-type mice. Humanperipheral blood mononuclear cells were cell cultures most commonly used inidentified in vitro studies, following by human endothelial cells cultures.DENV-2 strains were most used.
Conclusions: in conclusion, a largebody of in vivo and in vitro evidences showed that oxidative/nitrosativestress can be related to production of pathogenesis-related protein, increasedsusceptibility of mice to DENV infection, hemorrhage development in mice, proinflammatorycytokines and transcriptional factor expression, and DENV replication in variouscell cultures.

【 授权许可】

CC BY-NC