A systematic review of observational studies on oxidative/nitrosative stress involvement in dengue pathogenesis

Colombia Médica

Raimundo Castro-Orozco²  Nelson Alvis-Guzmán³  Hernando Samuel Pinzón-Redondo¹ 

[1] Fundación Hospital Napoleón Franco Pareja;Universidad de San Buenaventura, Cartagena;Universidad de CartagenaFundación Hospital Inflantil Napoleón Franco Pareja

关键词: Dengue;    severe dengue;    dengue virus;    oxidative stress;    nitrosative stress;    biological markers;    systematic review;   

DOI  :  

学科分类：医学（综合）

来源: Universidad del Valle * Facultad de Salud / Universidad del Valle, Faculty of Health

【 摘 要 】

Abstract ObjectiveOur objective was to systematically review the published observational research related to the role of oxidative-nitrosative stress in pathogenesis of dengue.MethodsWe searched electronic databases (PubMed, EMBASE, The COCHRANE library, ScienceDirect, Scopus, SciELO, LILACS via Virtual Health Library, Google Scholar) using the term: dengue, dengue virus, severe dengue, oxidative stress, nitrosative stress, antioxidants, oxidants, free radicals, oxidized lipid products, lipid peroxides, nitric oxide, and nitric oxide synthase. Articles were selected for review by title and abstract excluding letter, review,in vivoandin vitrostudies, and duplicates studies. Selected articles were reviewed for study design, original purposes, sample size, main outcomes, methods, and oxidative-nitrosative stress markers values.ResultsIn total, 4331 non-duplicates articles were identified from electronic databases searches, of which 17 were eligible for full text searching. Data from the observational studies originate from Asian countries (52,9%; 9/17), South American countries (29.4%; 5/17), and Central America and the Caribbean countries (17.7%; 3/17). Case-control study was the type of design most common in researches reviewed. The 1997 World Health Organization (WHO) dengue case classification criteria were used in all studies included in this review.Conclusions Based on published data found in peer-reviewed literature, oxidative and nitrosative stress are demonstrated by changes in plasma levels of nitric oxide, antioxidants, lipid peroxidation and protein oxidation markers in patients with dengue infection. Additionally, elevated serum protein carbonyls and malondialdehyde levels appear to be associated with dengue disease severity.

【 授权许可】

Unknown