Evaluation of toxicity of Cuban plant extracts with possible antiparasitic action based on the use of Artemia salina larvae

Revista Cubana de Medicina Tropical

Fernández-Calienes Valdés, Aymé¹  Gutiérrez Gaitén, Yamilet²  Acuña Rodríguez, Deyanira¹  Sariego Ramos, Idalia¹  Monzote Fidalgo, Lianet¹  Scull Lizama, Ramón²  García Parra, Marley¹  Mendiola Martínez, Judith¹ 

[1] Instituto de Medicina Tropical Pedro Kourí., Ciudad de La Habana, Cuba;Instituto de Farmacia y Alimentos, Ciudad de La Habana, Cuba

关键词: toxicidad;    extractos de plantas;    Artemia salina;   

DOI  :  

学科分类：传染病学

来源: SciELO

【 摘 要 】

INTRODUCTION: Artemia salina lethality assay is considered a useful tool to determine preliminary toxicity of plant extracts. In our labs some plant species are studied because of their antiparasitic potentials.OBJECTIVE: to evaluate A. salina nauplii mortality caused by ethanol extracts of Cuban medicinal plants.METHODS: A. salina larvae were exposed to four concentrations of 35 ethanol extracts from 34 plant species, for 24 hours. Mean Lethal Concentration (LC50) was determined to classify each extract into the categories of extremely toxic, highly toxic, mildly toxic or non toxic.RESULTS: out of the tested extracts, only 5 (Artemisia absinthium, Luffa cylindrica, Melia azedarach, Melaleuca leucadendron and Simarouba glauca) were classified as extremely or highly toxic, 13 as mildly toxic whereas 17 extracts (48,5 %) were non toxic exhibiting LC50 values over 1 000 µg/mL.CONCLUSIONS: most of the evaluated extracts showed low toxicity, which is a positive result. The five extremely toxic extracts will not be included in further studies.

【 授权许可】

CC BY-NC