Association between the Severity of Hashimoto's Disease and the Functional +874A/T Polymorphism in the Interferon-γ Gene

Endocrine Journal

Chisato ITO¹  Chikami WATANABE¹  Yoshinori IWATANI¹  Mikio WATANABE¹  Noriko OKUDA¹ 

[1] Department of Biomedical Informatics, Division of Health Science, Osaka University Graduate School of Medicine

关键词: IFN-γ;    Single nucleotide polymorphism;    Disease severity;    Ethnic difference;    Type 1 helper T cell;   

DOI  :  10.1507/endocrj.K06-015

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(23)Cited-By(26)CD8+CD25+-activated cytotoxic T cells and anti-thyroglobulin antibodies (TgAb) are independently involved in the severity of Hashimoto's disease (HD). Interferon γ (IFN-γ) activates cytotoxic T cells. To evaluate the hypothesis that the functional +874A/T polymorphism in the gene encoding IFN-γ is associated with the severity of HD, we examined the frequencies of this polymorphism in 34 HD patients who developed hypothyroidism (severe HD); 22 untreated, euthyroid HD patients (mild HD); 49 patients with intractable Graves' disease (GD); 16 GD patients in remission; and 57 healthy volunteers. Frequency of the +874T allele, which is associated with high IFN-γ production, was higher in patients with severe HD than in those with mild HD (odds ratio [OR], 3.5; 95% confidence interval [CI], 1.0-12.4; p = 0.047), but there was no difference in the frequency between GD patients. The difference in the frequency of +874T was observed in the subset of patients with HD negative for TgAb (OR, 8.4; 95% CI, 1.2-57.3; p = 0.029) but not in the subset of patients with HD positive for TgAb. Our data indicate that the +874A/T polymorphism in the IFN-γ gene is associated with severity of HD.

【 授权许可】

Unknown