Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase

Endocrine Journal

Mi-Kyung Lee²  Hyeon Jeong Lee¹  Cheol Ryong Ku¹  Eun Jig Lee¹  Eun Young Lee¹  Suk Kyoung Kim¹ 

[1] Endocrinology, Severance Hospital Integrative Research Institute for Cerebral & Cardiovascular Diseases, Yonsei University College of Medicine, Seoul, Korea;Pathology, National Health Insurance Corporation, Ilsan Hospital, Koyang, Korea

关键词: Resveratrol;    Pancreatic β-cell;    Poly(ADP-ribose) polymerase;    Streptozotocin;   

DOI  :  10.1507/endocrj.EJ11-0194

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(20)Cited-By(14)Resveratrol (3,5,4’-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many effects on metabolic diseases.This study aimed to evaluate the protective effect of RSV pretreatment on β-cell.Male Sprague Dawley rats weighing 200-230 g were divided into 4 groups: (1) RSV; (2) streptozotocin (STZ, 70 mg/kg, intraperitoneally); (3) STZ after 7 days pretreatment with RSV; and (4) STZ pretreated with nicotinamide.Fasting glucose concentration was measured and an intraperitoneal glucose tolerance test was performed 72 h after STZ injection to determine the diabetic condition.The pancreas was removed 3, 6, 36, and 48 h after STZ injection.STZ induced diabetes in all rats not given RSV pretreatment, whereas none of the RSV-pretreated rats developed diabetes.Pretreatment with RSV inhibited apoptosis and reduced the activation of caspase-3 and poly(ADP-ribose) polymerase (PARP).However, expression of the total length PARP was not affected by pretreatment.Our findings suggest that RSV protects β-cells from STZ simultaneously with inhibiting the activation of PARP.

【 授权许可】

Unknown