Increased synthesis of poly(ADP‐ribose) in isolated liver nuclei from autoimmune NZB/NZW mice

FEBS Letters

Lee, Jeremy S.¹  Sibley, John T.¹  Haug, Brenda L.¹ 

[1] Departments of Biochemistry and Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 0W0, Canada

关键词: Poly(ADP-ribose) polymerase;    Enzyme metabolism;    Autoimmunity;    (Liver nucleus;    Mouse);   

DOI  :  10.1016/0014-5793(87)80156-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The synthesis and degradation of poly(ADP-ribose) were investigated in isolated liver nuclei from autoimmune NZB/W mice and four strains of normal mice. Compared to normal mice the maximum levels of incorporation of P[³H]NAD into poly(ADP-ribose) were increased about 2-fold in the autoimmune mice. The kinetics of incorporation suggested that this change was due to an increase in the activity of the polymerase rather than a decrease in the level of degradative enzymes. Thus there may be a connection between autoimmunity and poly(ADP-ribose) metabolism.

【 授权许可】

Unknown