High-density lipoprotein subspecies between patients with type 1 diabetes and type 2 diabetes without / with intensive insulin therapy

Endocrine Journal

Tsutomu Hirano¹  Tomoyasu Fukui¹ 

[1] Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine. Tokyo 142-8666, Japan

关键词: High-density lipoprotein subspecies;    Type 1 diabetes;    Type 2 diabetes;    Intensive insulin therapy;   

DOI  :  10.1507/endocrj.EJ11-0329

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(33)Cited-By(6)The reduced levels of high-density lipoprotein (HDL) 2-cholesterol (C) in diabetes and other metabolic disorders associated with a high risk of cardiovascular disease are well established.Few studies, however, have compared the HDL subspecies in type 1 diabetes (T1D) with those in type 2 diabetes (T2D) with or without insulin.We examined HDL subspecies in 27 T1D with insulin, 33 T2D with insulin or insulin plus oral-anti-diabetic drugs (OADs), 36 T2D with OADs or diet/exercise, and 25 non-diabetic controls.Insulin was injected four times daily in a basal-bolus manner for both T1D and T2D.Plasma levels of C, apolipoprotein (apo) AI, and AII were determined in HDL2 and HDL3 by the single precipitation method.HDL-C levels were significantly higher in T1D and lower in T2D, compared with the controls.Insulin-treated T2D had higher HDL-C than non-insulin-treated T2D.T1D had higher HDL2-C and HDL2-apo AI levels than T2D.Insulin-treated T2D had higher HDL2-C and HDL2-apo AI levels than non-insulin-treated T2D.All of these differences were more pronounced for men than for women.HDL3 levels were comparable among controls,T1D and T2D.HDL2-C levels were inversely associated with BMI, HbA1c, triglyceride, small dense LDL-C, and LDL-C.Multiple regression analysis revealed that HDL2-C was independently associated with triglyceride, LDL-C, and intensive insulin therapy but not with HbA1c.In conclusion, these results suggest that intensive insulin therapy is associated with alterations of HDL subspecies, irrespective of the type of diabetes.

【 授权许可】

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