Relationship between serum secreted frizzled-related protein 4 levels and the first-phase of glucose-stimulated insulin secretion in individuals with different glucose tolerance

Endocrine Journal

Fang Liu¹  Yingjie Li¹  Hua Qu¹  Hang Wang¹  Huacong Deng¹  Qian Tang¹  Zesong Yang¹ 

[1] Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, P.R.China

关键词: Secreted frizzled-related protein 4;    First-phase of insulin secretion;    Intravenous glucose tolerance test;    IL-1β;    Diabetes;   

DOI  :  10.1507/endocrj.EJ15-0212

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(32)Cited-By(1)Recent evidence suggests that serum secreted frizzled-related protein (SFRP) 4 may affect β-cell function.In a cross-sectional clinical study, 56 subjects with type 2 diabetes mellitus (T2DM), 52 subjects with impaired glucose tolerance (IGT) and 42 normal glucose tolerance (NGT) subjects were enrolled to investigate the relationship between SFRP4 levels and the first-phase of glucose-stimulated insulin secretion, glucose metabolism and inflammation.Intravenous glucose tolerance tests were conducted, and acute insulin response (AIR), the area under the curve of the first-phase (0-10 min) insulin secretion (AUC), and the glucose disposition index (GDI) were calculated.The serum levels of SFRP4, IL-1β, plasma glucose, serum lipid, and glycated hemoglobin (HbA1c) were measured.Levels of serum SFRP4 and IL-1β in the T2DM group and IGT group were significantly higher than those in the NGT group (P < 0.01).The AIR, AUC and GDI between the three groups showed a progressive decrease from the NGT to IGT groups with the lowest value in the T2DM groups (P < 0.01).The serum SFRP4 levels were negatively correlated with AIR, AUC, GDI and HOMA-β (P < 0.01) and were positively correlated with fasting plasma glucose, HbA1c, hs-CRP, and IL-1β (P < 0.01).Our study provides evidence that the concentrations of serum SFRP4 in T2DM and IGT subjects were increased and were correlated closely with glycose metabolic disorder, the first-phase of glucose-stimulated insulin secretion and chronic low-grade inflammation.SFRP4 may participate in the development of type 2 diabetes mellitus.

【 授权许可】

Unknown