Increased secreted frizzled-related protein 4 and ficolin-3 levels in gestational diabetes mellitus women

Endocrine journal

Ming Zhang¹  Hui-yan Wang²  Xiao-song Yuan³ 

[1] Department of Laboratory Medicine, Changzhou Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, China;Department of Obstetrics and Gynecology, Changzhou Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, China;Department of Prenatal Diagnosis Laboratory, Changzhou Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, China

关键词: Gestational diabetes mellitus;    Secreted frizzled-related protein 4;    Ficolin-3;   

DOI  :  10.1507/endocrj.EJ17-0508

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

By biochemical and epidemiological similarity with type 2 diabetes mellitus (T2DM), gestational diabetes mellitus (GDM) has some overlap between prediction markers and risk factors of T2DM. The present study aimed to establish that secreted frizzled-related protein 4 (SFRP4) and ficolin-3 levels, which have been linked to insulin resistance and the development of T2DM, are elevated in GDM women. A longitudinal prospective cohort study of 86 GDM and 273 normal glucose tolerant (NGT) pregnant women was performed. The clinical parameters, lipid profiles, and serum SFRP4 and ficolin-3 levels were tested during the early and late second-trimester and third-trimester of pregnancy. Both SFRP4 and ficolin-3 levels were significantly higher in GDM women as compared to the NGT participants at three test points (p < 0.01). Spearman’s correlation analysis showed that serum SFRP4 levels were significantly positively correlated with ficolin-3 during the early and late second-trimester and third-trimester of pregnancy. The elevated SFRP4 and ficolin-3 concentrations at 16–18 weeks gestation significantly associated with GDM were conformed using binary logistic regression analysis after controlling for other variables [odds ratios (OR) with 95% confidence intervals (CI) for SFRP4: 2.84 (1.78–4.53), p < 0.01; for ficolin-3: 2.45 (1.55–3.88), p < 0.01]. In Conclusions, increased SFRP4 and ficolin-3 levels are significantly associated with GDM development and might be important risk factors for this pregnancy complication.

【 授权许可】

Unknown