Acromegaly Associated with Monoclonal Gammopathy of Undetermined Significance (MGUS)

Endocrine Journal

Norio MURAKAMI¹  Ippei KANAZAWA¹  Yuzuru KATO¹  Toshitsugu SUGIMOTO¹  Yuko YAMANE¹  Toru YAMAGUCHI¹ 

[1] Department of Endocrinology/Metabolism and Hematology/Oncology, Shimane University Faculty of Medicine

关键词: Acromegaly;    MGUS;    Multiple myeloma;    Growth hormone;    Insulin-like growth factor-I;   

DOI  :  10.1507/endocrj.K05-173

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(11)Cited-By(2)Here we report the case of a 65-year-old woman with acromegaly complicated with monoclonal gammopathy of undetermined significance (MGUS). The patient visited Shimane University Hospital for treatment of spinal canal stenosis, and was diagnosed as acromegaly with GH 43.1 ng/ml, insulin-like growth factor (IGF)-I 510 ng/ml and the detection of a pituitary adenoma by MRI. She was also diagnosed as MGUS with IgG 2208 mg/dl, the existence of IgG-κ type monoclonal protein, and 5.6% plasma cells in bone marrow. After a pituitary adenoma was operatively removed by transsphenoidal approach, IgG levels, as well as GH and IGF-I levels, decreased spontaneously and simultaneously. We suspect a pathogenetic link between acromegaly and MGUS in this case, because both GH and IGF-I are known to directly promote immunoglobulin production from plasma cells, thus inducing the proliferation of the cells in vitro.

【 授权许可】

Unknown