Antidepressant-Like Effect of Venlafaxine Is Abolished in μ-Opioid Receptor–Knockout Mice

Journal of Pharmacological Sciences

George R. Uhl³  Ichiro Sora⁴  Kazutaka Ikeda⁵  Kumatoshi Ishihara²  Soichiro Ide¹  Masabumi Minami¹  Shunsuke Fujiwara²  Masayuki Fujiwara² 

[1]Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Japan

[2]Laboratory of Neuropharmacology, Faculty of Pharmaceutical Sciences, Hiroshima International University, Japan

[3]Molecular Neurobiology, National Institute on Drug Abuse, USA

[4]Department of Biological Psychiatry, Tohoku University Graduate School of Medicine, Japan

[5]Division of Psychobiology, Tokyo Institute of Psychiatry, Japan

关键词: μ-opioid receptor;    knockout mouse;    antidepressant;   

DOI  :  10.1254/jphs.10136SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(10)Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP–knockout (KO) mice. Venlafaxine reduced immobility time in wild-type mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressant-like effects of venlafaxine.

【 授权许可】

Unknown