Syzygium cumini bark extract in controling glycemia and oxidative stress of normal and diabetic rats

Ciência Rural

Morsch, Vera Maria²  Mazzanti, Cinthia Melazzo²  Miron, Vinícius²  Schossler, Deila Rosély²  Filappi, Andreane²  Morsch, André²  Balz, Daniela²  Cecim, Marcelo¹  Prestes, Danívia²  Schetinger, Maria Rosa Chitolina² 

[1] Universidade Federal de Santa Maria, Santa Maria;Universidade Federal de Santa Maria

关键词: Black Plum;    Syzygium cumini;    alloxan;    diabetes;    oxidative stress     INTRODUÇÃOA diabetes melito compreende um grupo heterogêneo de transtornos hiperglicêmicos;    que afetam o metabolismo de carboidratos;    lipídeos e proteínas e estão associados com uma deficiência absoluta ou relativa na secreção e/ou ação da insulina (RAO et al;   

DOI  :  10.1590/S0103-84782003000600010

学科分类：农业科学（综合）

来源: Universidade Federal de Santa Maria * Centro de Ciencias Rurais

【 摘 要 】

The plant Syzygium cumini, also known as Black Plum is used widely in the popular medicine for the treatment of diabetes mellitus. This study verified the efficiency of the extract of the bark of Syzygium cumini on the glycemic levels and oxidative stress of normal and diabetic rats induced by alloxan. The animals were divided in control group (C), control treatment group (CT), diabetic control group (DC) and diabetic treatment group (DT). Oral administration of the aqueous extract of the bark of Syzygium cumini, in the dose of 1g/kg live weight, for a period of thirty days, did not result in a significant reduction on glycemia or on glucosilated hemoglobin levels. The treatment with the extract demonstrated an increase in the levels of thiobarbituric acid reactive substances (TBA-RS) in the plasma of the DT group (P <0.05), compared to the C. Kidney catalase activity of rats in DC group decreased significantly (P <0.01) and, in the liver, it showed a significant elevation in group DC (P <0.01). Those results indicated that the extract of Syzygium cumini bark does not possess hypoglycemic effect in alloxan diabetic induced rats. The antioxidant effect of this plant was not enough to reduce the production of TBA-RS significantly. The decrease of catalase activity in the kidneys can be owed to its exhaustion or inhibition, and its increase in the liver could be due to oxidative stress caused by the diabetic status.

【 授权许可】

CC BY-NC