Contribution of Fasting and Postprandial Hyperglycemia to Hemoglobin A1c in Insulin-Treated Japanese Diabetic Patients

Endocrine Journal

Yutaka UEHARA¹  Hiroyuki SHIMIZU¹  Masatomo MORI¹  Shuichi OKADA¹ 

[1] Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine

关键词: Hemoglobin A1c;    Insulin;    Postprandial hyperglycemia;    Diabetes mellitus;   

DOI  :  10.1507/endocrj.K07E-142

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(8)Cited-By(4)The contribution of fasting and postprandial glucose to hemoglobin A1c (HbA1c) levels was evaluated in insulin-treated patients. In 57 insulin-treated, diabetic out-patients, fasting glucose (before breakfast (B-FG), lunch (L-FG) and dinner (D-FG)) and postprandial glucose (B-PPG, L-PPG and D-PPG) levels were determined by the patients themselves at home using glucose self-monitoring apparatus over the course of one week. The correlation between HbA1c levels and self monitored blood glucose levels were calculated. In the conventionally treated group, there was a significant correlation between HbA1c and fasting glucose (FG) levels only before lunch, but at 2 hr after (PPG) all meals. In the intensively treated group, a significant correlation between HbA1c levels and FG levels was found before lunch and at 2 hr after breakfast and dinner. In all subjects, only FG levels before lunch correlated significantly with HbA1c levels, although PPG levels were significantly correlated with HbA1c at all points. The correlation was highest with PPG after breakfast and dinner. The sum of all FG, PPG and FG + PPG levels was significantly correlated with HbA1c levels. Postprandial hyperglycemia after breakfast and dinner should be regarded as most important for improving HbA1c levels in insulin treated diabetic patients.

【 授权许可】

Unknown