Journal of Veterinary Medical Science | |
Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice | |
Saya TAKAHASHI1  Shin-ichi HASHIDA1  Fumitoshi ASAI1  Motoi KURATANI1  Mitsuyuki SHIRAI1  Noriyuki KAJI1  Dai NAGAKUBO1  Norihiko HIRAI1  | |
[1] Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan | |
关键词: blood coagulation time; mouse; obese; rat; visceral fat; | |
DOI : 10.1292/jvms.13-0029 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(19)The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Leprfa (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.
【 授权许可】
Unknown
【 预 览 】
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