Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice

Journal of Veterinary Medical Science

Saya TAKAHASHI¹  Shin-ichi HASHIDA¹  Fumitoshi ASAI¹  Motoi KURATANI¹  Mitsuyuki SHIRAI¹  Noriyuki KAJI¹  Dai NAGAKUBO¹  Norihiko HIRAI¹ 

[1] Department of Pharmacology, Azabu University School of Veterinary Medicine, 1–17–71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252–5201, Japan

关键词: blood coagulation time;    mouse;    obese;    rat;    visceral fat;   

DOI  :  10.1292/jvms.13-0029

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Leprfa (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.

【 授权许可】

Unknown