Comparison of the IgG Subclass Distribution of Anti-thyroid Peroxidase Antibodies in Healthy Subjects with That in Patients with Chronic Thyroiditis

Endocrine Journal

FUMIHIRO YAMAGUCHI²  KIMIYUKI SAITO³  TOICHIRO HOSOYA²  MASAMI KIJIMA¹  HAJIME TSUNOO¹  YOICHI KOHNO³  HIROO NIIMI³ 

[1] Meiji Institute of Health Sciences;Faculty of Pharmaceutical Sciences, Chiba University;Department of Pediatrics, School of Medicine, Chiba University

关键词: Anti-thyroid peroxidase antibody;    Chronic thyroiditis;    IgG subclass;    Natural antibody;    Thyroid peroxidase;   

DOI  :  10.1507/endocrj.40.317

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(14)Cited-By(6)The IgG subclass distribution of anti-thyroid peroxidase (TPO) antibodies in patients with chronic thyroiditis and in healthy subjects has been investigated. Anti-TPO antibodies in sera of patients with chronic thyroiditis were predominantly associated with IgG1, with a lesser contribution by IgG4 and IgG3. In contrast, anti-TPO antibodies of healthy subjects were exclusively associated with IgG4. Since structural differences in IgG subclasses reflect differences in their biological roles, these findings suggest that the role of anti-TPO antibodies in patients may differ from that in healthy subjects.

【 授权许可】

Unknown