Protective Effects of Bio-Active Ceramic Water on Alcohol-Induced Hepatic Injury in Pigs

Journal of Veterinary Medical Science

Tae-Hwan KIM²  Won-Il JEONG²  Chang-Woo LEE²  Kyu-Shik JEONG²  Yoo-Kyeong KIM¹  Dong-Hyung NOH²  Oh-Deog KWON²  Sun-Hee DO²  Da-Hee JEONG² 

[1] Teacher's College, Kyungpook National University;Department of Veterinary Pathology, College of Veterinary Medicine, Kyungpook National University

关键词: active ceramic water;    alcohol;    fibrosis;    liver;    swine;   

DOI  :  10.1292/jvms.67.403

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(35)Cited-By(7)Among many detrimental injuries, alcohol is implicated in hepatitis, fatty liver, hepatic fibrosis, and cirrhosis. The purpose of this study was to evaluate the protective effect of bio-active ceramic water on alcohol-induced hepatic injury in pigs. Twelve male Landrace pigs were divided into 3 groups. Groups 1, 2, and 3 were fed with bio-active ceramic water + normal liquid diet, bio-active ceramic water + liquid diet containing 15% ethanol, and tap water + liquid diet containing 15% ethanol for 12 weeks, respectively. For serological, histopathological, and immunohistochemical analysis, all pigs were sacrificed at week 12. In group 3, serum ALT and AST levels increased, and mild fatty change and moderate necrosis were detected in the liver. Collagen fibers, myofibroblasts, and CYP2E1 were also increased or activated in group 3. In group 2, there were mild hepatic injuries compared to group 3. However, injuries and activations were not observed in the liver in group 1. We suggest that the bio-active ceramic water used in the present study had protective capability against ethanol-induced hepatic injury and that having no toxic effect on the pig liver. The bio-active ceramic water might be useful as a therapeutic drinking water in patients suffering from alcoholic liver diseases.

【 授权许可】

Unknown