Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs

Journal of Veterinary Medical Science

Jun SASAKI⁴  Eun-Sil PARK¹  Kazuyuki UCHIDA¹  Hye-Sook CHANG³  Hiroyuki NAKAYAMA¹  Mizue OGAWA¹  Hiroaki KAMISHINA²  Osamu YAMATO³ 

[1] Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University;Laboratory of Clinical Pathology, Department of Veterinary Clinical Sciences, Faculty of Agriculture, Kagoshima University;Department of Veterinary Pathology, Faculty of Agriculture, Iwate University

关键词: canine;    degenerative myelopathy;    oxidative stress;    Pembroke Welsh Corgi;   

DOI  :  10.1292/jvms.11-0097

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(9)Immunohistochemistry was performed to assess whether oxidative stress and/or denatured proteins play roles in the pathogenesis of canine degenerative myelopathy (DM). Two Pembroke Welsh Corgi (PWC) dogs with a homozygous mutation (c.118G>A) in the canine superoxide dismutase 1 (SOD1) gene were examined. The pathological features of the dogs were consistent with those of previous cases of DM in PWC. In the spinal lesions, diffuse SOD1 expression was observed in the neurons while no inclusion-like aggregates had formed, which disagreed with the findings of a previous study. A unique inducible nitric oxide synthase (iNOS) staining pattern in reactive astrocytes and a significant increase in ubiquitin immunoreactivity in the spinal lesions were also observed. These findings indicate the involvement of oxidative stress and the accumulation of ubiquitinated proteins in the pathogenesis of canine DM, whereas the role of SOD1 remains unclear.

【 授权许可】

Unknown