Cytotoxic Effect of the Her-2/Her-1 Inhibitor PKI-166 on Renal Cancer Cells Expressing the Connexin 32 Gene

Journal of Pharmacological Sciences

Hiromi Hagiwara³  Hiromi Sato¹  Kiyokazu Hagiwara³  Sumiko Shirai³  Etsuko Negishi¹  Keiko Fukumoto³  Eriko Fujimoto¹  Koichi Ueno¹  Tomohiro Yano³  Hiroshi Yamasaki² 

[1] Department of Geriatric Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Chiba University;Department of Cell Biology, Faculty of Science and Technology, Kwansei Gakuin University;Department of Food Science Research for Health, National Institute of Health and Nutrition

关键词: connexin 32;    PKI-166;    renal cancer cell;   

DOI  :  10.1254/jphs.SCJ04009X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(3)We have reported that connexin (Cx) 32 acts as a tumor suppressor gene in renal cancer cells partly due to Her-2 inactivation. Here, we determined if a Her-2/Her-1 inhibitor (PKI-166) can enhance the tumor-suppressive effect of Cx32 in Caki-2 cells from human renal cell carcinoma. The expression of Cx32 in Caki-2 cells was required for PKI-166-induced cytotoxic effect at lower doses. The cyctotoxicity was dependent on the occurrence of apoptosis and partly mediated by Cx32-driven gap junction intercellular communications. These results suggest that PKI-166 further supports the tumor-suppressive effect of the Cx32 gene in renal cancer cells through the induction of apoptosis.

【 授权许可】

Unknown