Background Lesions during a 24-Month Observation Period in Connexin 32-Deficient Mice

Journal of Veterinary Medical Science

Kazuhisa FURUHAMA¹  Toshihiko MAKINO²  Wataru TAKASAKI²  Yoko SUZUKI²  Isao IGARASHI²  Kiyonori KAI²  Munehiro TERANISHI² 

[1] Department of Veterinary Basic Medicine, Iwate University, Morioka, Iwate 020–8550, Japan;Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd., Fukuroi, Shizuoka 437–0065, Japan

关键词: connexin 32;    intercellular communication;    knock-out mice;    spontaneous mass;   

DOI  :  10.1292/jvms.12-0280

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(24)Cited-By(2)Connexin 32 (Cx32) is a major gap junction protein in the liver. Neoplastic and non-neoplastic lesions were examined in Cx32-deficient (Cx32KO) mice maintained for 24-month, and compared with those in wild-type mice as a corresponding control. In neoplastic lesions, hepatocellular carcinoma increased significantly only in male Cx32KO mice, suggesting that Cx32 deficiency may be related to their pathogenesis. For females, the incidence of pituitary adenoma in the pars distalis of Cx32KO mice was lower than that of wild-type mice. No non-neoplastic lesions related to Cx32-deficiency were observed in the Cx32KO mice. In conclusion, these results demonstrate that the incidence of hepatocellular carcinoma increases only in male Cx32KO mice, presumably due to enhanced tumor promotion and progression signals associated with Cx32 deficiency.

【 授权许可】

Unknown