Epidemiology and Etiology of Acute Encephalitis Syndrome in North India

Japanese Journal of Infectious Diseases

Amita Jain¹  Kaleshwar Prasad Singh¹  Parul Jain¹  G. Arun Kumar²  Shantanu Prakash¹  Ravindra Kumar Garg⁴  Danish Nasar Khan¹  Rashmi Kumar³  Arvind Kumar¹ 

[1] Virology Laboratory, Department of Microbiology, King George's Medical University;Manipal Center for Virus Research, Manipal University;Department of Paediatrics, King George's Medical University;Department of Neurology, King George's Medical University

关键词: acute encephalitis syndrom;    North India;    viral aetiology;    epidemiology;   

DOI  :  10.7883/yoken.67.197

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(41)Cited-By(5)Acute encephalitis syndrome (AES) is a major public health problem in eastern Uttar Pradesh, claiming thousands of lives every year. Here we report the common viral etiologic agents of AES and its epidemiology in the vicinity of Lucknow in Uttar Pradesh, North India. Cerebrospinal fluid (CSF) samples collected from patients with AES, who were referred to a viral diagnostic laboratory from January 2011 to December 2012, were tested for IgM antibodies against Japanese encephalitis virus (JEV), dengue virus (DV), herpes simplex virus (HSV), measles virus, mumps virus, varicella zoster virus (VZV), and enterovirus using commercial enzyme immuno-assays. Of the 1,578 enrolled patients, JEV was the most commonly detected (16.2%), followed by DV (10.8%), HSV (9.3%), measles virus (8.9%), mumps virus (8.7%), VZV (4.4%), and enterovirus (0%). Co-positivity with more than 1 virus was observed in 12 patients. The demographic distribution of patients pertaining to age, sex, and geographic and seasonal variation is discussed. Maximum mortality was caused by JEV infection, while patients with HSV infection had maximum residual neuro-psychiatric disability. JEV and DV are the chief causative agents of AES in North India, although other viruses should also be considered in a differential diagnosis.

【 授权许可】

Unknown