Effect of M-711 on Experimental Skin Reactions Induced by Chemical Mediators in Rats

Journal of Veterinary Medical Science

Kazuhiro SHICHINOHE¹  Masumi SHIMIZU¹  Kazuo KUROKAWA¹ 

关键词: allergic dermatitis;    Chinese herbal medicine;    Moku-boi-to;    rat;   

DOI  :  10.1292/jvms.58.419

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)Cited-By(4)We investigated the mechanism of anti-allergic action of Moku-boi-to (M-711) and effects on the skin reactions induced by chemical mediators as the model of allergic dermatitis. More than 20 mg/kg BW of M-711 significantly suppressed the enhancement of capillary permeability induced by histamine, LTC4, and anti-serum in the rat skin. Anti-histaminic effect of 40 mg/kg BW of M-711 was equipotent to same as the optimal doses of azelastine and diphenhydramine, respectively. As to anti-LTC4 action, 20 mg of M-711 was compared to the optimal dose of diphenhydramine. Those data showed that M-711 has the suppressive effects on the chemical mediators such as histamine and LTC4 and reduced the skin reaction induced by antigen-antibody response.

【 授权许可】

Unknown