Effect of Collagen Oligopeptide Injection on Rabbit Tenositis

Journal of Veterinary Medical Science

Prasarn TANGKAWATTANA¹  Takafumi WATANABE²  Aya NAGAYASU²  Jun MINAGUCHI²  Yasuo KOKAI¹  Yoshinao HOSAKA²  Kazushige TAKEHANA²  Natsuko MEGURI²  Hiromi UEDA² 

[1] Department of Biomedical Engineering, School of Medicine, Sapporo Medical University;Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University

关键词: collagen fibril;    collagen oligopeptide;    electron microscopy;    glycosaminoglycans;    rabbit tendon;   

DOI  :  10.1292/jvms.70.1295

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(39)Cited-By(2)Effects of the collagen oligopeptide (COP) were examined by its repeat injection into the inflammatory rabbit Achilles tendon (Tendo calcaneus communis), in which tenositis was induced by injection of bacterial collagenase. COP was evaluated 5 times over a period of 3 weeks to 1 month after injection of collagenase. At 1 month after treatment, the therapeutic effect of COP was evaluated by examining the structure of collagen fibrils, amount and components of glycosaminoglycans (GAGs) and matrix metalloproteinases (MMPs), and compared with the saline injection, control, and normal groups. The Achilles tendon of rabbit in the control group (no COP injection) and saline injection group showed a notable increase in the number of fine collagen fibrils, a change in GAG composition and increase in the amount of pro-MMP-2, indicating the weakening of the tendon. In contrast, the size distribution of collagen fibrils, GAG composition and the amount of pro-MMP-2 was similar to those in the normal group. These results suggest that COP injection promotes healing processes of the tendon injury.

【 授权许可】

Unknown