Morphometric analysis of cornea in the Slc39a13/Zip13-knockout mice

The Journal of Veterinary Medical Science

Naoki TAKAHASHI¹  Takuya HIROSE²  Ippei SUZUKI³ 

[1] Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen 40002, Thailand;Laboratory of Microanatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan;Molecular and Cellular Physiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770-8055, Japan

关键词: collagen fibril;    cornea;    morphometry;    Slc39a13/Zip13-knockout mice;   

DOI  :  10.1292/jvms.18-0019

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

Ehlers-Danlos syndrome (EDS) is a group of hereditary diseases caused by mutation of extracellular matrix-related genes. Recently, spondylodysplastic EDS-Zip13 (spEDS-Zip13: OMIM 612350) was recognized as a new EDS type. This current study could reveal various morphometric differences of collagenous population in the proper substance of cornea between the wild type and spEDS-Zip13-knockout (Zip13-KO) mice. Blockade of Smad-signaling pathway might initiate these alterations. Predilected dissimilarity in level of transcriptional activity probably dictated morphology of keratocyte and shape and electron density of its nucleus. In addition, the imbalance of proteoglycans and glycosaminoglycans would also affect the diameter and arrangement of collagen fibrils. These findings would be considered as vulnerable characteristics of corneal stroma of the Zip13-KO mice.

【 授权许可】

Unknown