Ability of CD8+ T Cell Anti-Feline Immunodeficiency Virus (FIV) Activity and FIV Proviral DNA Load in Mononuclear Cells in FIV-Infected Cats

Journal of Veterinary Medical Science

Tsutomu HOHDATSU¹  Hiroyuki KOYAMA¹  Isao SAITO¹  Tsubasa NAKANISHI¹ 

[1] Department of Veterinary Infectious Diseases, School of Veterinary Medicine and Animal Sciences, Kitasato University

关键词: CD8+ T cell;    FIV;    proviral DNA load;   

DOI  :  10.1292/jvms.67.129

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Cited-By(3)We investigated the relationship between CD8+ T cell anti-feline immunodeficiency virus (FIV) activity and FIV proviral DNA load integrated in mononuclear cells. The anti-FIV activity and the proviral DNA load were correlated, and the number of proviral DNA copies was high in cats with decreased anti-FIV activity. Particularly, no anti-FIV activity was detected in the cats staged as having an acquired immunodeficiency syndrome (AIDS)-related complex or AIDS, and the number of proviral DNA copies was obviously increased compared to those in the cats in the asymptomatic stage. These results suggest that decreased anti-FIV activity destroys the control of in vivo FIV replication, which leads to an increased proviral DNA load with the progression of the clinical stage of disease.

【 授权许可】

Unknown