Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Pivotal Advance: Nonfunctional lung effectors exhibit decreased calcium mobilization associated with reduced expression of ORAI1 | |
关键词: CD8+ T cell; function; regulation; NFAT; TCR signal transduction; | |
DOI : 10.1189/jlb.0809575 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
CD8+Tcellsplayacriticalroleintheclearanceofrespiratorypathogens.Thus,itissurprisingthatfunctionalinactivationoflungeffectorshasbeenobservedinmanymodelsofviralinfection.Currently,themoleculardefectresponsiblefortheshut‐offoffunctioninthesecellsisunknown.Inthepresentstudy,weaddressedthisquestionusingamodelofrespiratoryinfectionwiththeparamyxovirusSV5.NonfunctionalcellswerefoundtoexhibitdecreasesinSOCE,resultinginreducedNFAT1activation.Notably,functioncouldberestoredbytheprovisionofincreasedlevelsofextracellularcalcium.ThereducedabilitytomobilizecalciumwasassociatedwithreducedexpressionofORAI1,theCRACchannelsubunit.ThesefindingsrevealapreviouslyunknownmechanismforthenegativeregulationoffunctionineffectorTcells...
【 授权许可】
CC BY
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