The Intelligent Data Management System for Toxicogenomics

Journal of Veterinary Medical Science

Jae-Woong HWANG⁵  Gyoum-Jung LEE²  Yang-Seok KIM³  Chan-Dong YEO²  Gyoung-Jae LEE²  Chan-Hwi UM³  Jun-Sub KIM¹  Ki-Seon JEON³  Yong-Soon LEE⁵  Jong-Soo KANG²  Seok-Il HONG⁴  Yong-Hyun KIM¹  Seung-Jun KIM¹  Joon-Suk PARK⁵  Kyung-Sun KANG⁵  Seung Yong HWANG¹  Wan-Seon LEE³ 

[1] Department of Biochemistry and Molecular Biology, Hanyang University & Genocheck Co., Ltd.;Research Institute. Shin-Won Scientific Co., Ltd.;Bioinformatics Unit, ISTECH Inc.;Department of Laboratory Medicine, Korea Institute of Radiological & Medical Sciences;Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University

关键词: cDNA microarray;    data management;    toxicogenomics;   

DOI  :  10.1292/jvms.66.1335

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(19)Cited-By(2)Toxicogenomics is now emerging as one of the most important genomic application because the toxicity test based on gene expression profiles is expected to be more precise and efficient than current histopathological approaches in a pre-clinical phase. One of the challenging issues in toxicogenomics is the construction of intelligent database management system which can deal with heterogeneous and complex data from many different experimental and information sources. TEST(Toxicogenomics for Efficient Safety Test) database is especially focused on the connectivity of heterogeneous data and the intelligent query system which enable users to obtain relevant useful information from the complex data sets. The database deals with four kinds of information; compound, histopathology, gene expression, and annotation information. Currently, TEST database maintains toxicogenomics information for 16 compounds, 45 microarrays, 190 animal experiments, and customized 4.8 K rat clone set. Our presented system is expected to be a good information source for studying of toxicology mechanism in the genome-wide level and can also be applied to the designing toxicity test chip.

【 授权许可】

Unknown