Synthesis, Characterization and Biological Activities of Organotin (IV) Methylcyclohexyldithiocarbamate Compounds | Science Publications

American Journal of Applied Sciences

Normah Awang¹  Ibrahim Baba¹  Bohari M. Yamin¹  Nurul F. Kamaludin¹  Mohd S. Othman¹ 

关键词: Salmonella typhimurium;    infrared spectra;    biological activities;    staphylococcus aureus;    antibacterial activity;    synthesized compounds;    disc diffusion;    elemental analysis;   

DOI  :  10.3844/ajassp.2011.310.317

学科分类：自然科学（综合）

来源: Science Publications

【 摘 要 】

Problem statement: The growing interest in the chemistry of sulphur donor ligands are dueto their encouraging anticancer, antibacterial and antifungal activities as well as their widespreadindustrial application. Dithiocarbamates belong to this class and much attention has been paid to them.Approach: Novel organotin compounds with the molecular formula R_mSn[S₂CN(CH₃)(C₆H₁₁)]_4-m(where m = 2, R = CH₃, C₂H₅; m = 3, R = C₆H₅) have been synthesized using in situ method. Thesecompounds were characterized by elemental analysis, IR, ¹H and ¹³C NMR spectroscopy. Results:Elemental analysis revealed that all compounds were of good purity. Infrared spectra of thecompounds showed that the thioureide ?(C-N) band was in the region 1450-1500 cm^?1. The unsplittingband of ?(C-S) in the region 974-979 cm^?1indicated the bidentate nature of the chelateddithiocarbamato legends. The 13C NMR chemical shift of the carbon atom in the N-CS₂ group appearedin the range of 196.29-199.82 ppm. Single crystal analysis from one of these compounds showed that thechelating mode of the dithiocarbamate groups was isobidentate. These compounds have been screenedfor antibacterial activity against four bacteria; Staphylococcus aureus, Salmonella typhimurium,Pseudomonas aeruginosa and Bacillus subtilis. Only one of these compounds shows promising resultsagainst S. aureus and S. typhi. Cytotoxicity screening on human leukemic promyelocyte HL-60 cellsfound that two of these compounds were very active with CD₅₀ values of 0.87 and 0.18 µg mL^?1.Conclusion: The studied compounds were found to have the potential in biological activity especiallyin cytotoxicity where this possibly can be used for clinical trials after further research.

【 授权许可】

Unknown