Relationship between NF-κB Expression and Malignancy of Canine Mammary Gland Tumor Tissues

Journal of Veterinary Medical Science

Tassanee JAROENSONG¹  Lobna MKAOUAR¹  Takayuki NAKAGAWA¹  Kazuyuki UCHIDA²  He Xi JUN²  Hiroyuki NAKAYAMA²  Nobuo SASAKI¹  Soo-Jung LEE¹  Manabu MOCHIZUKI¹  Yoshifumi ENDO¹ 

[1] Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: canine MGT;    immunohistochemistry;    malignancy;    NF-κB;    prognosis;   

DOI  :  10.1292/jvms.11-0380

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(29)Cited-By(2)In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.

【 授权许可】

Unknown